Beilstein J. Org. Chem.2014,10, 858–862, doi:10.3762/bjoc.10.82
isomers – cuevaenes A (1) and C (3) as well as cuevaenes D (4) and E (5) – and cuevaene B (2) were isolated from gdmAI-disrupted Streptomycessp. LZ35. The constitution of cuevaene C (3) was found to be identical to cuevaene A (1) by means of NMR spectroscopy and high resolution mass spectrometry. However
; geometrical isomer; natural products; Streptomycessp. LZ35; Introduction
Cuevaenes are polyketides containing 3-hydroxybenzoic acid (3-HBA). Only 4 naturally occurring cuevaenes are described. Cuevaenes A and B were isolated from Streptomyces sp. HKI 0180 fifteen years ago and display moderate antibacterial
triene structural moiety is rarely found in natural products.
Streptomycessp. LZ35 was isolated from the intertidal soil collected at Jimei, Xiamen, China [3]. An orphan type I polyketide synthase gene cluster that contains a putative chorismatase/3-hydroxybenzoate synthase gene was identified by genome
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Graphical Abstract
Figure 1:
Cuevaenes A–E (1–5) isolated from Streptomyces sp. LZ35.